Description
Dosage and Administration
Administration Route:
Intravenous (IV) use only.
Side Effects
- Injection Site Reactions:
Pain, burning, or stinging at the injection site. - Cardiovascular Effects:
Hypotension (low blood pressure) and bradycardia (slow heart rate). - Respiratory Effects:
Transient apnea (temporary cessation of breathing) following induction doses. - Neurological Effects:
Involuntary muscle movements, including myoclonus. - Propofol Infusion Syndrome (PRIS):
A rare but potentially fatal condition characterized by metabolic acidosis, rhabdomyolysis, hyperkalemia, and cardiac failure, particularly with prolonged, high-dose infusions. - Severe Hypersensitivity Reactions:
Anaphylaxis and angio. - Severe Cardiovascular Depression:
Profound hypotension and asystole.
Precautions
- Administration by Trained Personnel:
Propofol should only be administered by individuals trained in the provision of general anaesthesia and airway management. - Monitoring
Continuous monitoring of respiratory and cardiovascular functions is essential during
