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Enzacept

Enzacept

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Enzacept
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Enzacept

Category:
Composition: Enzalutamide Capsules
Strength: 40mg

Description:

Enzacept (Enzalutamide 40 mg Capsules) is an androgen receptor inhibitor used in the treatment of prostate cancer. It is a novel hormonal therapy that blocks the action of androgens (male hormones), which fuel the growth of prostate cancer cells.
Enzalutamide is particularly effective in castration-resistant prostate cancer (CRPC) and metastatic hormone-sensitive prostate cancer (mHSPC).
Enzalutamide works by binding to the androgen receptor and inhibiting multiple steps in the androgen receptor signaling pathway:

  • Prevents androgen binding
  • Inhibits nuclear translocation of the androgen receptor
  • Blocks DNA binding and transcription of androgen-responsive genes

This triple-action mechanism suppresses cancer cell proliferation and promotes cancer cell death.

Enzacept is indicated for:

  • Metastatic castration-resistant prostate cancer (mCRPC)
  • Non-metastatic castration-resistant prostate cancer (nmCRPC)
  • Metastatic hormone-sensitive prostate cancer (mHSPC)
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Description

Dosage and Administration
  • Recommended dose: 160 mg once daily (i.e., 4 capsules of 40 mg) with or without food.
  • Should be taken at the same time each day.
  • Continue with a concurrent GnRH analogor following surgical castration, if applicable.
  • Dose modifications may be needed in case of toxicity or liver impairment.
  • Back pain
  • Hot flashes
  • Hypertension
  • Diarrhea
  • Weight loss
  • Joint pain
  • Fatigue
  • Seizures (rare but serious)
  • Falls and fractures
  • Cognitive disorders (memory impairment, confusion)
  • Cardiovascular events (monitor blood pressure regularly)
  • Not recommended during pregnancy or breastfeeding; contraindicated in women.
  • Caution in patients with a history of seizures or brain injury.
  • Regular monitoring of blood pressure, liver function, and mentalstatus is advised.
  • Avoid driving or operating machinery if experiencing dizziness, seizures, or mental fog.
  • Inform the healthcare provider of all concurrent medications to avoid interactions.