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Crizalk 250

Crizalk 250

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Crizalk 250
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Crizalk 250

Category:
Composition: Crizotinib
Strength: 250 mg

Description:

Crizalk 250 (Crizotinib) is a targeted anticancer medication used to treat specific types of non-small cell lung cancer (NSCLC). It is an oral tyrosine kinase inhibitor that works by blocking abnormal proteins that drive cancer cell growth, particularly in tumors with ALK (anaplastic lymphoma kinase) or ROS1 gene rearrangements.

By inhibiting ALK and ROS1, Crizalk slows or stops the growth of cancer cells and helps to shrink tumors, offering an important treatment option for patients whose tumors are driven by these genetic mutations.

Uses / Indications:

  • Treatment of patients with ALK-positive metastatic non-small cell lung cancer (NSCLC)
  • Treatment of patients with ROS1-positive metastatic NSCLC

The presence of ALK or ROS1 gene alterations must be confirmed through approved testing before starting therapy.

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Description

Dosage and Administration
  • The recommended dose is 250 mg taken orally twice daily, with or without food.
  • Swallow the capsules whole; do not crush, chew, or open them.
  • Dose adjustments may be necessary based on tolerability and side effects.

Always follow the prescribing doctor’s instructions carefully.

  • Vision disorders (blurred vision, double vision)
  • Nausea, vomiting, diarrhea
  • Swelling (edema)
  • Constipation
  • Fatigue
  • Decreased appetite
  • Liver enzyme abnormalities
  • QT interval prolongation (heart rhythm problem)
  • Pneumonitis (lung inflammation)
  • Bradycardia (slow heart rate)

Patients should seek immediate medical attention if they experience symptoms like shortness of breath, chest pain, or fainting.

  • Liver function, heart function, and blood counts should be monitored regularly.
  • Not recommended during pregnancy or breastfeeding.
  • Use effective contraception during treatment and for some time after the last dose.

Inform the doctor about any pre-existing heart, liver, or lung conditions.